When it comes to relationships between characters in an anime series, only on rare occasions do I find myself detouring from the series narrative. Unfortunately, on these rare occasions that it does happen, I wind up having strong opinions about their incorrect decision. I have yet to finish watching Domestic Girlfriend, simply because I am nervous that the obvious choice (i.e. Rui) won't be picked.
As far as this comic, Re:Zero is a great anime series that features one of the best, if not the best, girl: Rem. You know who isn't the best girl? Emilia. Emilia who? Exactly.